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At Aster Publications, we are committed to advancing knowledge and fostering innovation by publishing high-quality journals across all disciplines of Science, Technology, Engineering, and Mathematics (STEM). Our publications provide a platform for researchers, academics, and professionals to share groundbreaking discoveries, cutting-edge methodologies, and insightful reviews. We strive to ensure rigorous peer-review processes and open access options to promote the dissemination of valuable research to the global community. Join us in our mission to drive progress and inspire the next generation of STEM leaders.

Recently Published Article(s)

Construction of Dual Gene-activated Matrix Via Coaxial Electrospinning and Its Application in Periodontal Tissue Regeneration

Geng Liu, Chun-Xia Chen, Xue Chang, Li-Li Wang

Objective: This study aimed to construct a dual gene-activated Matrix (GAM) via coaxial electrospinning and to investigate its application in periodontal tissue regeneration.

Methods: Coaxial electrospinning was used to encapsulate polyethylenimine (PEI)/ osteoprotegerin plasmid (p-OPG) cores in poly (lactic-co-glycolic acid) (PLGA) to form a dual GAM with a core-shell structure. PEI-PLGA core–shell nanoscaffolds were also prepared as a control. The average fiber diameters, mechanical properties, cell toxicities, p-OPG release behaviors, and OPG protein expressions of the prepared materials were compared to determine the utility of the scaffolds. Mouse experiments were used to study the effects of the dual GAM scaffolds on osteogenesis rates and their value in periodontal tissue regeneration.

Results: There were no significant differences between the mean diameters (P > 0.05) and mechanical properties (P > 0.05) of the fibers in each sample. No p-OPG was released from the control sample, whereas the amount of p-OPG released from the research sample increased over time (P < 0.05). The optical densities of both samples increased over time and there was no significant difference between them (P > 0.05). Over time, the transient transfection efficiency of the research sample gradually decreased and the OPG protein expression gradually increased. This was significantly different from the results for the control sample (P < 0.05). Finally, the bone formation rate in the research sample was higher than that in the control sample (P < 0.05).

Conclusion: Coaxial electrospinning can be used to construct dual GAMs. A PEI/p-OPG-PLGA core–shell GAM scaffold was prepared and cultured with periodontal ligament stem cells. There was very little cytotoxicity and the OPG plasmid was slowly and continuously released, transfected to the target cells, and continuously expressed. In mouse experiments, the PEI/p-OPG-PLGA core–shell GAM scaffolds promoted bone growth, indicating that they have considerable potential for periodontal tissue regeneration.

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Evaluation of a Prototype Application for Supporting Visual-Graphic Symbol Acquisition in Preschool Aged Children with Complex Communication Needs

Susan S. Johnston, John M. Jameson, Benjamin A. Coletta, Gregory Bayles, Leddy Burdiss

Young children with complex communication needs can increase their ability to communicate efficiently and effectively through augmentative and alternative communication (AAC) but may experience barriers in acquiring a robust symbol vocabulary which includes learning the relationship between different symbols and their referents. An engaging app that utilizes evidence-based instructional strategies may serve as an efficient and effective tool for supporting vocabulary development and visual-graphic symbol knowledge. The purpose of this study was to design and develop an app to support visual-graphic symbol acquisition. Following development, an initial evaluation of the app was conducted with three young children with complex communication needs. This preliminary study utilized a within-subject; multiple-baseline probe design replicated across participants to examine the effectiveness of the app in teaching visual-graphic symbol acquisition for three target words.

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Anti-JOVI.1 Antibody to Detect Clonal T Cell Populations: Implementation into a Diagnostic Flow Cytometry Laboratory and Correlation with Clinical Findings

Benjamin Reardon*, Jennifer Hsu, Sandy Smith, Riana van der Linde, David A. Brown,  Elizabeth Tegg, and Sarah C. Sasson

The development of a high through-put flow cytometric assay for the identification of clonal T cells has proved challenging. We assessed the surface expression of a specific T Cell Receptor β-chain constant region using conjugated anti-JOV1.1 monoclonal antibodies to identify clonal T cell populations in a large diagnostic flow cytometry laboratory within a quaternary referral hospital. 37 cases were analysed. We identified 15 cases of clonal JOVI.1 expression, 7 of which had a consensus diagnosis of T-cell lymphoproliferative disease (TLPD). The remaining 22 cases had polyclonal JOVI.1 expression, none of which had a consensus diagnosis of TLPD, resulting in a sensitivity of 100% and specificity of 73%. When clonal NK-T cells were excluded, specificity further improves to 97%. These results provide real-world data and support the widespread adoption of this assay into diagnostic use.


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Efficacy of Mechanical, Subsonic, Ultrasonic and Photon-Induced Photoacoustic Streaming techniques in reducing Enterococcus faecalis in severely curved root canals: An ex vivo study

Osvaldo Zmener, Cornelis H Pameijer and Roberto Della Port

The aim of the study was to compare in vitro the efficacy of Photon-induced Photoacoustic Streaming (PIPS) with EndoActivator (EA), Ultrasound (PUI), XP-endo Finisher (XP) and conventional needle irrigation (CNI) in reducing Enterococcus faecalis from severely curved root canals. Fifty-four extracted human mandibular premolars with 35-45 degree canal curvature were prepared and irrigated with 5.25% sodium hypochlorite and 17% EDTA.

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Early Intervention Case Study: Bone-Anchored Hearing Aid (BAHA) Softband Fitting in Treacher Collins Syndrome

Diane Davis and Yula C. Serpanos

This retrospective case study reports on the successful auditory and language outcomes following bone-anchored hearing aid (BAHA) Softband fitting in a child with Treacher Collins syndrome (TCS) and moderately severe conductive hearing loss (CHL) resulting from bilateral aural atresia. Information is presented from birth to age 3 years. The timeframe of assessment and remediation services met 1-2-3-month early intervention target guidelines. The child received the medical intervention, a hearing diagnosis, and a remediation plan for BAHA Softband fitting along with family-centered early intervention support services, including speech and language

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Overdiagnosis and Overtreatment of COPD in Individuals 90 Years and Older 

OIkuyo Imayama, Mateo Tole, Christian J. Ascoli , Israel Rubinstein

Although the prevalence of chronic obstructive pulmonary disease (COPD) increases with age, limited information about the current diagnostic and therapeutic practices in COPD is available in aged individuals. We conducted a retrospective study of adults aged 90 years and older with COPD diagnosis and compared differences in prescribed medications, and steroid or antibiotic use for respiratory symptoms during acute healthcare visits across the four subgroups.

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Eye-gaze Profiles of Children with Autism Spectrum Disorder in Relation to Fast-mapping Abilities

Daiquirie L. Crumrine and Trisha L. Self

Children learn new words through a process termed fast-mapping, which involves pairing novel words and objects after minimal exposure. There have been studies conducted to understand the fast-mapping processes in children with typical development (TD); however, this phenomenon has received less attention for children with autism spectrum disorder (ASD). In addition, there was limited information that investigated the eye-gaze patterns and fast-mapping abilities of children with ASD and TD.

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Open access publishing at Aster Publications offers numerous benefits to authors. By making your research freely available to the global community, open access increases the visibility and impact of your work. This wider dissemination leads to higher citation rates, greater engagement from diverse audiences, and enhanced opportunities for collaboration. Authors also retain copyright, ensuring you have control over your work while contributing to the collective advancement of knowledge across all STEM disciplines.